Combination therapy with amphotericin-B and miltefosine for post-kala-azar dermal leishmaniasis: a preliminary report.
نویسندگان
چکیده
© 2014 The Authors. doi: 10.2340/00015555-1582 Journal Compilation © 2014 Acta Dermato-Venereologica. ISSN 0001-5555 Post-kala-azar dermal leishmaniasis (PKDL) is a recalcitrant dermatosis following apparent cure from visceral leishmaniasis (VL). Patients with PKDL are considered the sole reservoir for the parasite during inter-epidemic periods of VL in India (1). Mono-drug therapy has been recommended to date in PKDL, with the newer drug for PKDL are Miltefosine and Amphotericin-B while older drug is Sodium Stibogluconate. Combination treatments advocated for VL have yet to be formulated in PKDL. We describe here the treatment of 3 cases of PKDL that demonstrate the greater effectivness of treatment with a combination of amphotericin-B (AmB) and miltefosine (MIL) over AmB alone.
منابع مشابه
Post-kala-azar Dermal Leishmaniasis with Mucosal Involvement: An Unusual Case Presentation including Successful Treatment with Miltefosine
Post-kala-azar dermal leishmaniasis (PKDL) is a dermatologic manifestation that usually occurs after visceral leishmaniasis (VL) caused by Leishmania donovani. It is characterized by hypopigmented patches, a macular or maculopapular rash and nodular skin lesions on the body surface. Involvement of the mucosae is very rare and unusual in PKDL. We report a case of PKDL that presented with polymor...
متن کاملRenal involvement in leishmaniasis: a review of the literature
Leishmaniasis, an infectious disease endemic in tropical, Asian and southern European countries, is caused by obligate intramacrophage protozoa and is transmitted through the bite of infected female sandflies. More than 20 leishmanial species are responsible for four main clinical syndromes: cutaneous leishmaniasis; mucocutaneous leishmaniasis; visceral leishmaniasis, also known as kala-azar, a...
متن کاملDecline in Clinical Efficacy of Oral Miltefosine in Treatment of Post Kala-azar Dermal Leishmaniasis (PKDL) in India
BACKGROUND Recent studies have shown significant decline in the final cure rate after miltefosine treatment in visceral leishmaniasis. This study evaluates the efficacy of miltefosine in the treatment of post kala-azar dermal leishmaniasis (PKDL) patients recruited over a period of 5 years with 18 months of follow-up. METHODOLOGY In this study 86 confirmed cases of PKDL were treated with two ...
متن کاملDrug unresponsiveness & combination therapy for kala-azar.
Pentavalent antimonials (SbV) have been successfully used for treatment of kala-azar since last six decades. Since 1970s its conventional dosages have failed to achieve with 60 per cent unresponsiveness reported with WHO regimen in Bihar (India). Pentamidine initially used as a second line of drug, acquired resistance (25%) even with prolonged dosage. Newer oral drug miltefosine is a potent ant...
متن کاملEfficacy and Safety of Miltefosine in Treatment of Post-Kala-Azar Dermal Leishmaniasis
BACKGROUND Long regimens for the treatment of post-kala-azar dermal leishmaniasis (PKDL) result in noncompliance. A safe, effective, and acceptable regimen for the treatment of PKDL is still to be developed. Miltefosine has been found to be effective in the treatment of Visceral Leishmaniasis (VL). Hence, its efficacy was tested in patients of PKDL. METHODS In this exploratory study, 33 patie...
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ورودعنوان ژورنال:
- Acta dermato-venereologica
دوره 94 2 شماره
صفحات -
تاریخ انتشار 2014